UGT1A1基因多态性对药物代谢和临床作用影响的进展
投稿时间:2018-07-17  修订日期:2018-10-09  点此下载全文
引用本文:张喆,蔡卫民.UGT1A1基因多态性对药物代谢和临床作用影响的进展[J].药学实践杂志,2018,36(6):488~492
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作者单位E-mail
张喆 上海复旦大学药学院, 上海 201203  
蔡卫民 上海复旦大学药学院, 上海 201203 weimincai@fudan.edu.cn 
中文摘要:UGT1A1基因是参与人体代谢循环的重要基因,随着药物基因组学的发展,发现其基因多态性与某些药物代谢水平相关,进而影响疾病的发生、发展及治疗等诸多方面。随着研究进展,UGT1A1的底物在不断扩展,包括胆红素、雌激素、伊立替康及其他一些药物已有研究。研究UGT1A1基因多态性对药物代谢情况的影响,在临床疾病的诊治、预后判断及药物不良反应等方面有重要的指导意义。
中文关键词:尿苷二磷酸葡萄糖醛酸转移酶1A1  基因多态性  药物代谢  药物基因组学
 
Research progress on the effect of UGT1A1 gene polymorphisms on drug metabolism and clinical efficacy
Abstract:UGT1A1 is an important gene in the process of drug metabolism. With the development of pharmacogenomics,which have been found that the UGT1A1 gene polymorphisms is relevant to the level of metabolism, affect the occurrence,development and treatment of disease. As the study progressed, the substrates of UGT1A1 have constantly been extended, including bilirubin, estrogen, irinotecan and some other drugs with a number of studies. Research on the relationship between UGT1A1 gene polymorphisms and these substrates have showed that UGT1A1 gene polymorphisms play an important significance on the clinic diagnosis and treatment, prognostic judgments and drug side effects. The research progress of the role of UGT1A1 gene polymorphisms to drug metabolism and clinical effects were reviewed in this paper.
keywords:UGT1A1  gene polymorphisms  drug metabolism  pharmacogenomics
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