Th2相关炎症因子在湿疹发病中的作用机制
投稿时间:2018-09-28  修订日期:2018-11-20  点此下载全文
引用本文:朱聪聪,潘会君,朱全刚.Th2相关炎症因子在湿疹发病中的作用机制[J].药学实践杂志,2019,37(1):9~13
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作者单位E-mail
朱聪聪 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437
上海市皮肤病医院药剂科, 上海 200443 
 
潘会君 上海市皮肤病医院药剂科, 上海 200443  
朱全刚 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437
上海市皮肤病医院药剂科, 上海 200443 
qgzhu@126.com 
基金项目:上海市科委资助项目(17401901800)
中文摘要:湿疹是临床常见的炎症性皮肤病,具有剧烈瘙痒、反复发作等特点。其病因复杂,包括多种内、外因素相互作用。主要发病机制与Th2免疫应答失衡有关,相关的炎症因子更是发挥十分重要的作用。上皮衍生因子胸腺基质淋巴细胞生成素以及白介素-33(IL-33)能够引发Th2免疫失衡,促进IL-4、IL-5、IL-13等炎症因子分泌,后者进一步诱导嗜酸性粒细胞增多、IgE生成。综述Th2相关炎症因子在湿疹发病中的作用机制,对湿疹治疗具有重要意义。
中文关键词:湿疹  炎症因子  胸腺基质淋巴细胞生成素  白介素-4
 
Mechanism of Th2 related inflammatory factors in the pathogenesis of eczema
Abstract:Eczema is a common clinical inflammatory skin disease characterized by severe itching and recurrent attacks.Its etiology is complex, including a variety of internal and external factors.The main mechanism is related to the imbalance of Th2 immune response, and related inflammatory factors play an important role.Epithelial-derived factor like thymic stromal lymphopoietin and interleukin-33 could trigger Th2 immune imbalance and promote the secretion of type inflammatory factors such as interleukin-4, interleukin-5, and interleukin-13.These inflammatory factors will further induce eosinophilic granulocytosis and IgE formation.In this paper, the research progress of mechanism of type 2 related inflammatory factors in eczema were reviewed, which provided the great significance for treatment.
keywords:eczema  inflammatory factor  TSLP  IL-4
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