中药保健品中非法添加磷酸二酯酶-5抑制剂检测方法的研究进展
投稿时间:2018-03-07  修订日期:2018-12-29  点此下载全文
引用本文:丁德英,刘伟,吕狄亚.中药保健品中非法添加磷酸二酯酶-5抑制剂检测方法的研究进展[J].药学实践杂志,2019,37(2):103~108
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作者单位E-mail
丁德英 海军军医大学药学院, 上海, 200433  
刘伟 海军军医大学药学院, 上海, 200433  
吕狄亚 海军军医大学药学院, 上海, 200433 diyalv2008@yahoo.com.cn 
基金项目:国家自然科学青年科学基金项目(81603067)
中文摘要:本文综述了中药保健品中非法添加磷酸二酯酶-5(PDE-5)抑制剂的检测方法。目前,快速检测一般采用红外光谱法、近红外光谱法、薄层色谱与拉曼光谱联用法等;确证检测采用高效液相色谱法,液相色谱-质谱联用法等;在结构鉴别和确证上采用核磁共振法、气相色谱-质谱联用法等补充检测;还有一些X射线衍射、酶联免疫吸附等高效检测方法,为药品监督管理部门进行该类中药保健品掺杂的检测提供相关的技术方法,保障人民食品药品合理、安全的使用。
中文关键词:中药保健品  PDE-5抑制剂  掺杂  检测方法
 
Research progress on the detection methods for illegal addition of PDE-5 inhibitors in botanical dietary supplements
Abstract:The detection methods for the illegal addition of PDE-5 inhibitors in botanical dietary supplements were reviewed in this article. So far,FTIR,NIR,and TLC-SERS methods were commonly adopted to rapid detection,and confirmed detection by HPLC,LC-MS methods; NMR and GC-MS methods were used as supplementary tests for structural identification and confirmation. In addition,other high-efficiency detection methods such as XRD and ELISA also provided relevant technical methods for the drug supervision and administration department to carry out the detection of the doping of botanical dietary supplements and ensure that the reasonable and safe use of food and drug.
keywords:botanical dietary supplements  PDE-5 inhibitors  doping  detection methods
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