补肾阳与补肾阴中药抗骨质疏松作用的研究进展
投稿时间:2018-11-29  修订日期:2019-01-10  点此下载全文
引用本文:夏天爽,薛黎明,张巧艳,辛海量,李睿旻,秦路平.补肾阳与补肾阴中药抗骨质疏松作用的研究进展[J].药学实践杂志,2019,37(2):109~114,155
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作者单位E-mail
夏天爽 海军军医大学药学院, 上海 200433  
薛黎明 上海市疾病预防中心, 上海 200336  
张巧艳 海军军医大学药学院, 上海 200433
浙江中医药大学药学院, 浙江 杭州 310053 
 
辛海量 海军军医大学药学院, 上海 200433  
李睿旻 海军军医大学药学院, 上海 200433 daynes77@163.com 
秦路平 海军军医大学药学院, 上海 200433
浙江中医药大学药学院, 浙江 杭州 310053 
qinsmmu@126.com 
基金项目:国家自然科学基金资助项目(U1505226,U1603283)
中文摘要:骨质疏松症是一种由多因素引起的骨密度和骨质量降低的全身性骨病,其破坏性之大、受众面之广已严重危害人类身心健康。目前,临床上治疗骨质疏松的药物,如双磷酸盐类、雌激素类等多具有潜在的副作用,而传统中药因其安全、有效且副作用小的特点已逐渐成为治疗骨质疏松症的补充和替代药物。中医认为"肾主骨",肾虚则骨萎,因此采用补肾中药治疗骨质疏松症更是获得越来越多国内外学者的认可。补肾中药依据其作用效果的不同又分为补肾阳中药和补肾阴中药。对近年来补肾阳和补肾阴中药治疗骨质疏松症的作用及机制进行综述,旨在探索二者在治疗特点上的异同,为补肾中药抗骨质疏松的发展提供借鉴。
中文关键词:骨质疏松  中药  补肾阳  补肾阴
 
Research progress in anti-osteoporosis effects of the herbs tonifying kidney-yang and kidney-yin
Abstract:Osteoporosis (OP) is a systemic osteopathy with low bone mineral density and bone quality.It seriously endangered human physical and mental health due to its destructive and widespread characteristics.In clinic,drugs for OP,such as bisphosphonates and estrogens,have potential side effects.Contrarily,traditional Chinese medicine (TCM) has less adverse reactions and significant therapeutic effects.It becomes one of the remarkable complementary and alternative OP therapies.According to TCM theory,kidney is in charge of bone.The bone loss is attributed to the deficiencies of kidney.Therefore,herbs tonifying kidney had been used in the treatment of OP.Based on the different effects,herbs tonifying kidney are divided into tonifying kidney-yang and kidney-yin herbs.This paper reviews the effects and mechanisms of the herbs tonifying kidney-yang and kidney-yin in the OP treatment with the intention of exploring the similarities and differences of their treatment characteristics and providing reference for the development of kidney tonifying herbs in OP prevention and therapy.
keywords:osteoporosis  traditional Chinese medicine  tonifying kidney-yang  tonifying kidney-yin
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