珊瑚共附生真菌次级代谢产物研究进展
投稿时间:2018-10-02  修订日期:2019-03-04  点此下载全文
引用本文:王洪亮,张文.珊瑚共附生真菌次级代谢产物研究进展[J].药学实践杂志,2019,37(3):193~200,253
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作者单位E-mail
王洪亮 海军军医大学药学院 上海 200433
陆军军医大学士官学校 河北 石家庄 050000 
 
张文 海军军医大学药学院 上海 200433 wenzhang1968@163.com 
基金项目:国家自然科学基金(41576157)
中文摘要:近年来,珊瑚共附生真菌化学成分研究受到越来越多的关注,截至2014年底,已经从38种珊瑚中分离共附生真菌95种,涉及44个属,从中分离得到化合物200余个,这些化合物表现出抗肿瘤、抗真菌、抗炎和抗污等生物活性。珊瑚共附生真菌来源的新化合物数量呈逐年上升趋势,仅4年时间就发现化合物近百个,这些化合物显示出不同的生物活性。从化学结构和生物活性两个方面综述近4年对珊瑚共附生真菌次级代谢产物的研究进展,以期为进一步的深入研究提供参考。
中文关键词:珊瑚共附生真菌  次级代谢产物  化学结构  生物活性
 
Advances in secondary metabolites of coral epiphytic fungi
Abstract:More and more attentions had been paid to the chemical constituents of epiphytic fungi in coral.By the end of 2014,95 species of epiphytic fungi,involving 44 genera,were isolated from 38 coral species.More than 200 compounds were isolated from them.These compounds exhibited anti-tumor,anti-fungal,anti-inflammatory and anti-fouling biological activities.In recent years,the number of new compounds from coral epiphytic fungi had been increasing year by year,and nearly 100 compounds had been found in recent four years.These structures showed different biological activities.The progress on secondary metabolites of coral symbiotic epiphytic fungi in recent four years was reviewed from the aspects of chemical structure and biological activity,which could provide reference for further study.
keywords:coral epiphytic fungi  secondary metabolites  chemical structure  bioactivity
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